Successful rescue of a rare case of refractory shock due to multidrug toxicity: a case report

The treatment of mixed drug poisoning involving reserpine, metformin, and enalapril is very challenging. When resuscitating patients with refractory shock caused by such poisoning, early supportive therapies should be started, including gastric lavage, cathartic use, acid correction, improved ventilation, blood purification, and hemodialysis when needed. Additionally, vasoactive drugs may be given without an upper dose limit, as long as side effects are carefully monitored.

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Publication Details

Journal
Frontiers in Pharmacology
Published
2025-09-02
DOI
https://doi.org/10.3389/fphar.2025.1669831
Primary Topic
Poisoning and overdose treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Successful rescue of a rare case of refractory shock due to multidrug toxicity: a case report

Yunxing Cao, Yujie Zhou, Yuanyang Xie
Frontiers in Pharmacology
Poisoning and overdose treatments
article

Successful rescue of a rare case of refractory shock due to multidrug toxicity: a case report

Yunxing Cao, Yujie Zhou, Yuanyang Xie
article en

Abstract

The treatment of mixed drug poisoning involving reserpine, metformin, and enalapril is very challenging. When resuscitating patients with refractory shock caused by such poisoning, early supportive therapies should be started, including gastric lavage, cathartic use, acid correction, improved ventilation, blood purification, and hemodialysis when needed. Additionally, vasoactive drugs may be given without an upper dose limit, as long as side effects are carefully monitored.

Frontiers in PharmacologyVol. 16
Dalian Medical University (CN), Second Affiliated Hospital of Chongqing Medical University (CN), First People's Hospital of Chongqing (CN), Chongqing Medical University (CN)
Openalex Percentile: Top 65%
Poisoning and overdose treatments
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