Tissue expander breast reconstruction outcomes following postmastectomy radiation therapy in the era of neoadjuvant chemotherapy
Our study is the first to report TE-BR outcomes in women who undergo NAC versus AC in the context of PMRT. Our findings indicate inferior TE-BR outcomes following NAC when PMRT is delivered, emphasizing the importance of shared decision-making between patients and doctors about optimal surgical choice. If eligible, breast conservation or alternate BR technique should be strongly considered in the setting of NAC and future research should explore optimal reconstruction strategies.
Authors
- Oscar Padilla (ORCID: https://orcid.org/0000-0003-3878-937X)
- Allen Yen
- Leah Katz (ORCID: https://orcid.org/0000-0002-4428-1137)
- Meghan P. Jairam (ORCID: https://orcid.org/0000-0002-2780-4223)
- Eileen P. Connolly (ORCID: https://orcid.org/0000-0001-6558-1932)
- Jeffery Ascherman
- Elizabeth Buss (ORCID: https://orcid.org/0000-0002-5635-3513)
- Christine Chin (ORCID: https://orcid.org/0000-0002-8364-616X)
- Julie Choi (ORCID: https://orcid.org/0000-0003-3047-092X)
Institutions
- Brigham and Women's Hospital (US)
- Columbia University Irving Medical Center (US)
- Danbury Hospital (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.3389/fonc.2025.1636472
- Primary Topic
- Breast Implant and Reconstruction
- Type
- article
- Field-Weighted Citation Impact
- 0.00