RHBDF2 governs microglial neuroinflammation during cerebral ischemia–reperfusion injury and is positively regulated by the m6A reader YTHDF1
Microglial-specific RHBDF2 knockdown inhibits neuroinflammation in CIRI via STING-TBK1 signaling pathway, and is positively regulated by the m6A reader YTHDF1. This suggests RHBDF2 as a potential therapeutic target in ischemic stroke.
Authors
- Daifa Huang (ORCID: https://orcid.org/0009-0001-9719-3974)
- Xiuli Shang (ORCID: https://orcid.org/0000-0002-7555-1638)
- Ruonan Zhang (ORCID: https://orcid.org/0000-0002-7860-1231)
- Liwen Liu (ORCID: https://orcid.org/0000-0001-9838-5727)
- Lisi Xu (ORCID: https://orcid.org/0000-0003-2159-8024)
- Xiaolin Zhang (ORCID: https://orcid.org/0009-0005-9384-3844)
Institutions
- General Hospital of Shenyang Military Region (CN)
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1186/s10020-025-01326-y
- Citations
- 5
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- Natural Science Foundation of Liaoning Province