Increased ATP production and P‐glycoprotein activity underlie the marked changes in blood–brain barrier transport of drugs in a mouse model of amyotrophic lateral sclerosis
These findings open possible therapeutic avenues that could be exploited to overcome P-gp-mediated CNS drug resistance in ALS.
Authors
- Anup D. Shah
- Yoshiteru Kagawa (ORCID: https://orcid.org/0000-0003-2963-7905)
- Alanna G. Spiteri (ORCID: https://orcid.org/0000-0001-6787-6195)
- Dana S. Hutchinson (ORCID: https://orcid.org/0000-0001-9947-0106)
- Bradley J. Turner (ORCID: https://orcid.org/0000-0001-6580-7655)
- Cheng Huang (ORCID: https://orcid.org/0000-0003-3427-5937)
- Yijun Pan (ORCID: https://orcid.org/0000-0002-1442-3333)
- Joseph A. Nicolazzo (ORCID: https://orcid.org/0000-0002-0983-7152)
- Ralf B. Schittenhelm (ORCID: https://orcid.org/0000-0001-8738-1878)
- Pranav Runwal
- Jiaqi Sun (ORCID: https://orcid.org/0000-0002-6708-1883)
Institutions
- The University of Melbourne (AU)
- Tohoku University (JP)
- Florey Institute of Neuroscience and Mental Health (AU)
- Discovery Institute (US)
- Australian Regenerative Medicine Institute (AU)
- Perron Institute for Neurological and Translational Science (AU)
- Monash University (AU)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1111/bph.70147
- Citations
- 1
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Alzheimer's Association
- FightMND
- Monash University
- Medical Research Council
- National Health and Medical Research Council