Co-expression of PD1+ and HLA-DR+ in CD8+ T cells is increased in tonsils of children with EBV primary and persistent infection
These findings suggest that, during asymptomatic primary infection by EBV, activated CD8 T cells are observed, but they may be cells that may exhibit features of exhaustion, which probably explains the absence of symptoms. PD-1 expression in CD8 T cells remains in EC. Additionally, Tfh, Th1, and CD8 T cells may influence the expression of EBNA2 and LMP1 latent viral antigens in tonsils.
Authors
- Paola Chabay (ORCID: https://orcid.org/0000-0002-7355-3859)
- Elena De Matteo (ORCID: https://orcid.org/0000-0002-3856-0252)
- Plácida Baz
- Luis Ariel Billordo
- Alessandra Valerio (ORCID: https://orcid.org/0000-0001-5844-2256)
- María Eugenia Amarillo
- M. Soledad Collado
- Karen Lindl
- Veronica Lapido
- Ignacio E. Rojas Campión
- Johanna Speratti
Institutions
- Hospital de Clínicas "José de San Martín" (AR)
- Hospital General de Niños Ricardo Gutierrez (AR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1653165
- Primary Topic
- Viral-associated cancers and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Consejo Nacional de Investigaciones Científicas y Técnicas