Association between inflammatory markers (SII and SIRI) and anxiety levels in Parkinson’s disease

Our study demonstrates a significant positive linear association between SII and SIRI and anxiety levels, particularly state anxiety, in PD patients. These findings suggest that systemic inflammation may play a role in the development of anxiety in PD and highlight the potential utility of SII and SIRI as biomarkers for anxiety in this population. Future longitudinal studies are warranted to explore the causal relationship and potential therapeutic implications.