Sex differences in behavioral measures of anxiety in a recessive gene knockout (Pink1–/–) rat model of Parkinson’s disease
Unlike a surprising number of other rodent models of PD that fail to emulate clinically observed anxiety and/or male/female differences in these signs, the data presented here identify <i>Pink1<sup>-/-</sup></i> rats as strongly suited to lead translational efforts to better understand the neurobiological and neuroendocrine bases for anxiety symptoms in PD, their sex differences and their sex-specific sensitivities to therapeutic interventions.
Authors
- Mary F. Kritzer (ORCID: https://orcid.org/0000-0002-6628-1752)
- Sharon Feehan
Institutions
- Stony Brook University (US)
Publication Details
- Journal
- Frontiers in Behavioral Neuroscience
- Published
- 2025-09-02
- DOI
- https://doi.org/10.3389/fnbeh.2025.1646733
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Stony Brook University
- Thomas Hartman Center for Parkinson' Research, Stony Brook University