In situ sustained release of icariin from injectable thermosensitive PLGA-PEG-PLGA hydrogels combined with core decompression for steroid-induced osteonecrosis of femoral head
Our data showed that local injection of this sustained-release drug delivery system combined with CD could significantly relieve the glucocorticoid-induced early osteonecrosis in the rats model with SONFH by increasing the residence time of ICA in the necrotic area of femoral head to maximize the anti-apoptotic, pro-osteogenic and anti-adipogenic effects of ICA.
Authors
- Xiaonan Tang (ORCID: https://orcid.org/0000-0002-2434-9341)
- Kaige Xu
- Zehua Zhou (ORCID: https://orcid.org/0000-0002-8409-6307)
- Tao Li (ORCID: https://orcid.org/0000-0002-0698-2960)
- Yingxing Xu
- Yaping Jiang (ORCID: https://orcid.org/0000-0002-6614-0079)
Institutions
- Qingdao University (CN)
- Kunming Medical University (CN)
- Affiliated Hospital of Qingdao University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.3389/fphar.2025.1643316
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China