Duo biologic therapy using mepolizumab and omalizumab in refractory ABPA: two cases

This case series describes a novel approach for ABPA therapy that holds potential in improving patient outcomes for those with severe ABPA. Duo biologic therapy may improve disease control and reduce corticosteroid reliance in patients with refractory ABPA by targeting multiple mechanistic pathways of inflammation. Mepolizumab with Omalizumab offers a potential treatment strategy to reduce exacerbation frequency and severity and has minimal adverse effects.