Significantly higher incidence of circulating fatty objects in portal blood samples compared to peripheral blood samples in patients with pancreatic ductal adenocarcinoma
These findings suggest that CFOs originate from bile. It is probable that CFOs are insoluble bile lipids that have ebbed into the portal vein and subsequently shunted to the systemic circulation due to PDAC-induced hepatobiliary system abnormalities. It appears that hemofiltration can effectively remove CFOs from circulation.
Authors
- Ruoxiang Wang (ORCID: https://orcid.org/0000-0003-2614-8292)
- Kenneth H. Park (ORCID: https://orcid.org/0000-0002-5019-4339)
- Adrian Lim (ORCID: https://orcid.org/0000-0002-4638-9395)
- Stephen J. Pandol (ORCID: https://orcid.org/0000-0003-0818-6017)
- Rabindra R. Watson (ORCID: https://orcid.org/0000-0002-1429-7381)
- Mouad Edderkaoui (ORCID: https://orcid.org/0000-0002-2549-8242)
- Srinivas Gaddam (ORCID: https://orcid.org/0000-0001-6818-6305)
- Michael Lewis (ORCID: https://orcid.org/0000-0002-1892-4127)
- Quin Liu
- Yi Zhang (ORCID: https://orcid.org/0000-0001-7916-1752)
- Simon K. Lo
- Yan Ou (ORCID: https://orcid.org/0009-0006-9794-6055)
Institutions
- Cedars-Sinai Medical Center (US)
- VA Greater Los Angeles Healthcare System (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.3389/fonc.2025.1611872
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Cedars-Sinai Medical Center
- National Institutes of Health