Experimental validation of coarse ridge filters for FLASH proton therapy

The dose distribution obtained through carefully specified CEM proves robust to production errors typically occurring in commercial 3D printing. The robustness opens the way to simplified manufacturing of relatively complex parts. Owing to the beam configuration, the snout, and the range shifter, the CEM was able to generate clinical-quality dose distributions. The integration of the FLASH snout with its elements on the nozzle of the proton therapy system represents an important step forward in comparison to existing state-of-the-art, facilitating easier preclinical and future clinical trial investigations.