Bench-Stable Copper Complex for Trifluoromethylation and <sup>18</sup>F-Labeling of Aryl Iodides
Here, we report an efficient and highly active copper complex ([(TMPhen)<sub>2</sub>Cu(I)][O<sub>2</sub>CCF<sub>2</sub>Cl]) for the trifluoromethylation of aryl iodides. This bench-stable copper complex converts aryl iodides into their corresponding CF<sub>3</sub> derivatives in high yields within 1 h. The protocol is also well-suited for aromatic [<sup>18</sup>F]trifluoromethylation, offering a rapid and efficient approach for the development of new radiopharmaceuticals within 20 min.
Authors
- Jaelim Kim (ORCID: https://orcid.org/0000-0002-0432-2432)
- Ji Young Choi (ORCID: https://orcid.org/0000-0001-9593-4575)
- Ewa Pietrasiak (ORCID: https://orcid.org/0000-0003-4096-4544)
- Hyewon Youn (ORCID: https://orcid.org/0000-0003-1006-2689)
- Nakeun Ko (ORCID: https://orcid.org/0000-0001-9787-3251)
- Eunsung Lee (ORCID: https://orcid.org/0000-0002-1507-098X)
- Byung Chul Lee (ORCID: https://orcid.org/0000-0002-1425-5712)
- Seok-Yong Lee (ORCID: https://orcid.org/0009-0001-6381-5683)
Institutions
- Pohang University of Science and Technology (KR)
- Seoul National University (KR)
- New Generation University College (ET)
- Seoul National University Hospital (KR)
- Seoul National University Bundang Hospital (KR)
- National Institute of Ecology (KR)
- National University College (PR)
- Bioengineering Center (RU)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1021/acs.orglett.5c03171
- Citations
- 1
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.79
Funders
- National Research Foundation of Korea