Gestational diabetes increases preterm membrane rupture risk through elevated hydroxydesmethylpiperine sulfate levels
GDM elevates PROM risk by disrupting fetal membrane integrity through metabolic alterations. Elevated hydroxydesmethylpiperine sulfate levels in GDM-PROM cases indicate its potential as a PROM risk biomarker, underscoring the importance of early metabolic screening and glycemic control. Further research should explore this metabolite's mechanisms and therapeutic potential.
Authors
- Xingwang Ding
- Jinqi Ma (ORCID: https://orcid.org/0000-0001-5674-4023)
- Ying Li (ORCID: https://orcid.org/0000-0002-1683-7126)
- Tianshu Zhang (ORCID: https://orcid.org/0000-0002-4053-2349)
- Tianyu Shi (ORCID: https://orcid.org/0000-0003-4271-0871)
- Rong Lin
Institutions
- Wuxi People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.3389/fendo.2025.1631638
- Citations
- 1
- Primary Topic
- Preterm Birth and Chorioamnionitis
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Government of Jiangsu Province
- Nanjing Medical University