Integrated single-cell and bulk RNA-seq analysis reveals prognostic stemness genes in leiomyosarcoma
Our findings suggest that stemness-related heterogeneity in LMS shapes the tumor immune microenvironment and contributes to disease progression. The six identified prognostic markers not only provide insights into the molecular mechanisms of LMS but also represent potential therapeutic targets for personalized treatment.
Authors
- Long Zhang (ORCID: https://orcid.org/0000-0002-5125-0224)
- Huachi Li
- Tianqi Zheng (ORCID: https://orcid.org/0000-0002-2441-3833)
- Aiju Lou
- Ying Liang (ORCID: https://orcid.org/0000-0001-9092-2110)
- Yu‐Dong Cai (ORCID: https://orcid.org/0000-0001-5664-7979)
- Yupeng Hu
Institutions
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Liwan District Traditional Chinese Medicine Hospital (CN)
- Yancheng Third People's Hospital (CN)
- Hubei Cancer Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.3389/fonc.2025.1604413
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94