Secular trend of gestational diabetes mellitus and its interaction effect with advanced maternal age on adverse maternal-perinatal outcomes among primiparous singleton and twin pregnancies in Hubei, China (2011-2019)
Among younger women with singleton and twin gestations, the secular trend of GDM significantly increased between 2011 and 2019. Among singleton pregnancies, GDM is associated with an increased risk of several adverse maternal-perinatal outcomes in both younger and older women. The interaction effect between GDM and AMA significantly increased the risk of HDP, C-section, and preterm birth among singleton pregnancies.
Authors
- Hongtao Shen (ORCID: https://orcid.org/0000-0002-8553-7928)
- Jing Xu (ORCID: https://orcid.org/0000-0002-5304-7350)
- Nawsherwan Nawsherwan
- Ijaz ul Haq (ORCID: https://orcid.org/0000-0002-4852-2938)
- Shafaq Naeem (ORCID: https://orcid.org/0000-0002-7371-3744)
- Ghulam Nabi (ORCID: https://orcid.org/0000-0001-5256-0083)
- Xiaoqiu Ni (ORCID: https://orcid.org/0000-0003-2749-3899)
Institutions
- Jiangsu University (CN)
- Xiamen University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Wuhan University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Wenzhou Hospital of Traditional Chinese Medicine (CN)
- Nanjing Jiangning Hospital (CN)
- King Faisal University (SA)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.3389/fendo.2025.1439592
- Primary Topic
- Gestational Diabetes Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- King Faisal University
- Renmin Hospital of Wuhan University