Methanobactin rapidly facilitates biliary copper excretion in a Wilson disease rat model visualised by <sup>64</sup> Cu PET/MRI
A single i.p. methanobactin dose restored biliary copper excretion in LPP rats. The effect was more pronounced with ARBM101 than with MB-OB3b. Non-ATP7B transporters must be involved because ATP7B is absent in LPP rats. Methanobactin may have therapeutic potential in Wilson disease.
Authors
- Peter Ott (ORCID: https://orcid.org/0000-0002-3088-1983)
- Frederik Teicher Kirk (ORCID: https://orcid.org/0000-0002-3058-9042)
- Thomas Damgaard Sandahl (ORCID: https://orcid.org/0000-0001-9807-6852)
- Alan A. DiSpirito (ORCID: https://orcid.org/0000-0003-3602-6213)
- Aage Kristian Olsen Alstrup (ORCID: https://orcid.org/0000-0002-0084-9122)
- Jeremy D. Semrau (ORCID: https://orcid.org/0000-0002-1670-9984)
- Tamara Rieder
- Ditte Emilie Munk (ORCID: https://orcid.org/0000-0002-8077-2806)
- Karina Højrup Vase
- Hans Zischka (ORCID: https://orcid.org/0000-0002-4047-1566)
- Tea Lund Laursen (ORCID: https://orcid.org/0000-0003-2494-0526)
- Mikkel Holm Vendelbo (ORCID: https://orcid.org/0000-0003-0431-2522)
Institutions
- Iowa State University (US)
- Aarhus University (DK)
- University of Michigan (US)
- Aarhus University Hospital (DK)
- Helmholtz Zentrum München (DE)
- Regional Hospital Randers (DK)
- Technical University of Munich (DE)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1111/bph.70099
- Citations
- 1
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 1.12
Funders
- Aarhus Universitet