Exploring potential mechanistic aspects of “Biaoben acupoint” acupuncture for lumbar disc herniation using 4D proteomics
"Biaoben acupoint" acupuncture likely exerts its therapeutic effects by modulating multiple biological pathways related to inflammatory/immune responses, cytoskeleton organization, cell structure/adhesion, and tissue repair, thereby improving pain, lumbar function, and neurological deficits in LDH patients. Proteins such as CXCL12, ACTN1, CXCR4, and CCN2 are potential key mediators of these therapeutic effects.
Authors
- Zhiyi Wu (ORCID: https://orcid.org/0009-0007-9005-2304)
- Yadi Feng
- Yuzhang Liu (ORCID: https://orcid.org/0000-0003-2913-7150)
- Zuoxu Li
- Chun Chen (ORCID: https://orcid.org/0000-0002-3053-1019)
- Guojun Wang (ORCID: https://orcid.org/0000-0001-9875-4182)
- Shimin Zhang
- Fu‐Dong Shi (ORCID: https://orcid.org/0000-0002-9675-4637)
- Ning Liu (ORCID: https://orcid.org/0009-0008-1269-8553)
- Jin Jiao
- Hai Lin (ORCID: https://orcid.org/0000-0002-7995-7694)
Institutions
- Beijing University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Wangjing Hospital of China Academy of Chinese Medical Sciences (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.3389/fneur.2025.1630736
- Citations
- 3
- Primary Topic
- Musculoskeletal pain and rehabilitation
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- China Academy of Chinese Medical Sciences