ALOXE3 transcriptionally regulated by activating transcription factor 3 promotes HCC ferroptosis via ERK and JNK signaling pathway
RSL3-induced ROS accumulation activated ERK/JNK signaling, upregulating downstream ATF3 expression. ATF3 transcriptionally activated ALOXE3, promoting PUFA synthesis to enhance ferroptosis susceptibility in HCC and overcome sorafenib resistance.
Authors
- Jianwen Mao (ORCID: https://orcid.org/0000-0001-6590-6709)
- Kailin Xing
- Hongxin Zhou (ORCID: https://orcid.org/0000-0003-0326-045X)
- Wei‐Zhong Wu (ORCID: https://orcid.org/0000-0002-4936-7220)
- Hao Niu (ORCID: https://orcid.org/0000-0001-5200-2102)
- Dandan Dong (ORCID: https://orcid.org/0000-0002-7764-917X)
- Shuangshuang Dong (ORCID: https://orcid.org/0000-0003-0410-1207)
- Zhangfu Yang (ORCID: https://orcid.org/0000-0003-2359-9290)
- Shu-Xiu Xiao
- Dong-Min Shi
Institutions
- Fudan University (CN)
- Zhongshan Hospital (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1016/j.intimp.2025.115411
- Citations
- 3
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- Shanghai Science and Technology Development Foundation
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality