Increased granulovacuolar degeneration in the thalamus and higher neurofibrillary tangle Braak stages in bipolar disorder
These findings suggest that neurodegenerative processes, particularly tau pathology and CHMP2B-positive GVD in the PVT may play a role in BD pathophysiology.
Authors
- Mie Kubota‐Sakashita
- Araki Kimura
- Ito Kawakami (ORCID: https://orcid.org/0000-0003-1989-2398)
- Tadafumi Kato (ORCID: https://orcid.org/0000-0001-7856-3952)
- Kenichi Oshima
- Kenji Ikeda (ORCID: https://orcid.org/0000-0003-1380-4983)
- Akito Nagakura
Institutions
- Tokyo Metropolitan Matsuzawa Hospital (JP)
- Juntendo University (JP)
- Tokyo Metropolitan Institute of Medical Science (JP)
Publication Details
- Journal
- Psychiatry and Clinical Neurosciences
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1111/pcn.13891
- Citations
- 2
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Japan Agency for Medical Research and Development
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science