Pathological tau propagation from the brain to the colon via the vagal efferent pathway in Alzheimer’s disease
This study demonstrates that tau pathology can propagate from the brain to the colon via the vagus nerve, providing evidence supporting the brain-to-gut axis in AD.
Authors
- Hyunjung Choi (ORCID: https://orcid.org/0000-0001-6518-4750)
- Seok Chung (ORCID: https://orcid.org/0000-0002-1735-8338)
- Inhee Mook‐Jung (ORCID: https://orcid.org/0000-0001-7085-4085)
- Hui-Wen Liu
- June‐Hyun Jeong
- Seong‐Jun Kim (ORCID: https://orcid.org/0000-0001-8504-2872)
- Jin-Chul Ahn (ORCID: https://orcid.org/0009-0007-7493-4219)
- Dongjoon Lee (ORCID: https://orcid.org/0000-0001-6560-6001)
- Kyusik Ahn (ORCID: https://orcid.org/0000-0003-0258-6693)
- Jong Won Han (ORCID: https://orcid.org/0000-0002-6388-2392)
- Min‐Seon Kim (ORCID: https://orcid.org/0000-0002-9778-2760)
- Seok Beom Hong
- H Song
- Jae‐Hoon Song (ORCID: https://orcid.org/0009-0006-9652-3595)
Institutions
- Korea Institute for Advanced Study (KR)
- Seoul National University (KR)
- Korea University (KR)
- Asan Medical Center (KR)
- New Generation University College (ET)
- University of Ulsan (KR)
- Korea Institute of Brain Science (KR)
- Convergence Research Center for Diagnosis Treatment and Care System of Dementia (KR)
- Korea University (JP)
Publication Details
- Journal
- Gut
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1136/gutjnl-2024-334571
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea