Knockdown of ITGA2 Promotes Pyroptosis in Thyroid Cancer by Regulating the DNA Damage Response
<i>ITGA2</i> promotes TC progression by regulating the DNA damage response and inhibiting pyroptosis. Knockdown of <i>ITGA2</i> increases oxidative stress, exacerbates DNA damage, and inhibits the Wnt/β-catenin pathway, indicating it may have potential as a treatment target in TC.
Authors
- Jun Jiang (ORCID: https://orcid.org/0009-0000-3404-2071)
- Zhaolong Liu
- Dongming Hua
- Yu Feng (ORCID: https://orcid.org/0000-0003-4935-5366)
- Yan Liang (ORCID: https://orcid.org/0000-0002-6368-6471)
- Xiaoshuang Liu (ORCID: https://orcid.org/0000-0002-8829-7245)
- Rong Ying (ORCID: https://orcid.org/0009-0000-6341-9253)
Institutions
- Fudan University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Minhang District Central Hospital (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
- Shuguang Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-08-18
- DOI
- https://doi.org/10.31083/fbl27946
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00