LONP1 Promotes Hepatocarcinogenesis by Degrading ACO2 to Alleviate Ferroptosis
Our results suggest that LONP1 promotes HCC proliferation and migration by inhibiting ferroptosis and cuproptosis through the degradation of ACO2. Therefore, targeting LONP1 might be an effective therapeutic strategy to inhibit HCC growth.
Authors
- Zhendong Yu (ORCID: https://orcid.org/0000-0003-2142-3523)
- Liusheng Wu (ORCID: https://orcid.org/0000-0001-9580-2257)
- Wei Mao
- Erbao Chen (ORCID: https://orcid.org/0000-0003-0286-8754)
- Z PENG (ORCID: https://orcid.org/0000-0001-8750-8285)
- Xiaoqiang Li (ORCID: https://orcid.org/0000-0002-9692-1458)
- Ting Wang (ORCID: https://orcid.org/0000-0003-3433-5741)
- Yanfeng Zhong
- Bo Wu (ORCID: https://orcid.org/0009-0006-7697-2553)
Institutions
- National University of Singapore (SG)
- Peking University Shenzhen Hospital (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- Shenzhen Blood Center (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-08-29
- DOI
- https://doi.org/10.31083/fbl41226
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Guangdong Medical Research Foundation
- Basic and Applied Basic Research Foundation of Guangdong Province