Changes in Pre- and Post-Treatment Gut Microbiota and Metabolites in Neonates With Hyperbilirubinemia

This study demonstrates significant treatment-associated shifts in gut microbiota and metabolites in hyperbilirubinemic neonates, suggesting microbial dysbiosis may contribute to altered bilirubin metabolism. These findings highlight the potential of early microbiome-targeted interventions for managing neonatal jaundice and identify candidate therapeutic targets and biomarkers.

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Publication Details

Journal
Frontiers in Bioscience-Landmark
Published
2025-08-30
DOI
https://doi.org/10.31083/fbl42716
Primary Topic
Neonatal Health and Biochemistry
Type
article
Field-Weighted Citation Impact
0.00

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article

Changes in Pre- and Post-Treatment Gut Microbiota and Metabolites in Neonates With Hyperbilirubinemia

Yueyun Luo, Yan Liu, Longyi Mo, Dongzi Lin et al.
Frontiers in Bioscience-Landmark
Neonatal Health and Biochemistry
article

Changes in Pre- and Post-Treatment Gut Microbiota and Metabolites in Neonates With Hyperbilirubinemia

Yueyun Luo, Yan Liu, Longyi Mo, Dongzi Lin, Cheng Xu, Qian-Qi Chen, Minxiu Ye
article en

Abstract

This study demonstrates significant treatment-associated shifts in gut microbiota and metabolites in hyperbilirubinemic neonates, suggesting microbial dysbiosis may contribute to altered bilirubin metabolism. These findings highlight the potential of early microbiome-targeted interventions for managing neonatal jaundice and identify candidate therapeutic targets and biomarkers.

Frontiers in Bioscience-LandmarkVol. 30(8)
Guangdong Medical College (CN), The Fourth People's Hospital (CN)
University of Leicester
Openalex Percentile: Top 67%
Neonatal Health and Biochemistry
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