Humanized Fruit Flies as a Novel Pre-Clinical Test Model for Membrane Drug Transporters
Based on the handling procedure and the lack of need for Animal Protection Act approval, we propose that the humanized <i>Drosophila melanogaster</i> fruit fly model opens a new avenue for pre-clinical functional transporter studies.
Authors
- Jing Yang (ORCID: https://orcid.org/0000-0001-7372-0197)
- Anne T. Nies (ORCID: https://orcid.org/0000-0001-6862-0730)
- Elke Schaeffeler (ORCID: https://orcid.org/0009-0005-2997-0355)
- Simon U. Jaeger
- Bernard Moussian (ORCID: https://orcid.org/0000-0002-2854-9500)
- Yiwen Wang (ORCID: https://orcid.org/0000-0003-2069-6685)
- Matthias Schwab
Institutions
- Centre National de la Recherche Scientifique (FR)
- Tianjin University of Science and Technology (CN)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Nuremberg Hospital (DE)
- Tianjin Institute of Pharmaceutical Research (China) (CN)
- Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology (DE)
- Institut Sophia Agrobiotech (FR)
- University of Tübingen (DE)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-08-25
- DOI
- https://doi.org/10.31083/fbl42817
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00