Dendritic Cells Induce Clec5a-mediated Immune Modulation in MPTP-induced Parkinson’s Disease Mouse Model
These findings suggest that Clec5a plays a critical role in the immunomodulatory function of tolDCs. The administration of Clec5a-expressing DCs effectively reduced neuroinflammation and protected dopaminergic neurons in an MPTP-induced PD model. Therefore, Clec5a-expressing tolDCs may demonstrate therapeutic potential by managing PD symptoms by suppressing inflammatory responses associated with neurodegeneration.
Authors
- Jie Song (ORCID: https://orcid.org/0000-0002-5769-3886)
- Nam-Chul Jung (ORCID: https://orcid.org/0000-0002-9250-3304)
- So-Yeon Choi
- Min-Seon Song (ORCID: https://orcid.org/0000-0002-8634-3172)
- Ji-Hee Nam (ORCID: https://orcid.org/0009-0007-2372-9629)
- Kyung-Eun Noh (ORCID: https://orcid.org/0000-0002-7655-7089)
- Dae‐Seog Lim (ORCID: https://orcid.org/0000-0002-0637-4682)
- Ji-Soo Oh (ORCID: https://orcid.org/0000-0001-7862-1112)
- Jun‐Ho Lee (ORCID: https://orcid.org/0000-0002-8386-9275)
Institutions
- Korea Institute of Radiological and Medical Sciences (KR)
- CHA University (KR)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-08-30
- DOI
- https://doi.org/10.31083/fbl39570
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation of Korea