AURKA Suppresses Ferroptosis via the KEAP1/NRF2/HO‑1 Axis in EGFR-Mutant Lung Adenocarcinoma
Our findings demonstrate that AURKA promotes ferroptosis resistance in EGFR-mutant LUAD by modulating the KEAP1/NRF2/HO-1 axis. Notably, this effect was validated in the gefitinib-resistant EGFR T790M-mutant NCI-H1975 cell model. Our results highlight AURKA as a potential therapeutic target for overcoming epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) resistance and suggest that disrupting the AURKA/KEAP1/NRF2/HO‑1 pathway may offer a novel strategy for treating EGFR-mutant LUAD.
Authors
- Yufeng Huang (ORCID: https://orcid.org/0009-0000-1278-3805)
- Jun-hang Zhang (ORCID: https://orcid.org/0000-0002-7979-6093)
- Gengqiu Liu (ORCID: https://orcid.org/0000-0002-2376-1182)
- Liang Zhu (ORCID: https://orcid.org/0000-0002-8868-2768)
Institutions
- Sun Yat-sen University (CN)
- Guangdong Medical College (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Affiliated Hospital of Guangdong Medical College Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-08-29
- DOI
- https://doi.org/10.31083/fbl41293
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52