Inhibition of Galectin-3 Expression Could Preserve the Immunoregulatory Function of Mesenchymal Stem Cells During Cell Passaging
Gal-3 contributes to the decline in the immunomodulatory capabilities of MSCs. TD139, a Gal-3 inhibitor, has a potentially positive effect on rescuing the immunoregulation dysfunction of MSCs in late-passage and may represent a novel strategy to enhance the therapeutic potential of late-passage MSCs for GVHD treatment.
Authors
- Siguo Hao (ORCID: https://orcid.org/0000-0001-6381-7729)
- Yan Jiang
- Difan Zhang
- Minghui Wang
- Jiangbo Wan
- Fang Huang (ORCID: https://orcid.org/0000-0003-2285-7921)
Institutions
- XinHua Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-08-27
- DOI
- https://doi.org/10.31083/fbl39918
- Citations
- 1
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.80