Dissecting cross‐lineage tumourigenesis under p53 inactivation through single‐cell multi‐omics and spatial transcriptomics
Construction of a Trp53 functional cell landscape utilising single-cell multi-omics and spatial omics technologies. Reconstruction of p53 downstream regulatory relationships with lineage heterogeneity via machine learning-based gene network modelling. Dissection of shared and lineage-specific features during cross-lineage tumourigenesis under p53 deficiency.
Authors
- Lifeng Ma (ORCID: https://orcid.org/0000-0001-9865-9695)
- Guoji Guo (ORCID: https://orcid.org/0000-0002-1716-4621)
- Haofu Niu
- E Weigao
- Xiaoping Han (ORCID: https://orcid.org/0000-0003-3201-7635)
- Jinrong Peng (ORCID: https://orcid.org/0000-0002-0793-4848)
- Danmei Jia
- Yincong Zhou (ORCID: https://orcid.org/0000-0002-4798-8357)
- Xueyi Wang (ORCID: https://orcid.org/0000-0001-5533-5981)
- Qi Zhang (ORCID: https://orcid.org/0000-0003-0516-8008)
- Renying Wang (ORCID: https://orcid.org/0000-0002-4192-8054)
- Hanyu Wu
- Xing Fang (ORCID: https://orcid.org/0000-0002-9823-9620)
- Haide Chen (ORCID: https://orcid.org/0000-0002-1930-3867)
- Tingyue Zhang (ORCID: https://orcid.org/0009-0005-0629-4745)
- Yuqing Mei (ORCID: https://orcid.org/0000-0003-3438-0139)
- Shuang Zhang (ORCID: https://orcid.org/0000-0002-0857-8670)
- Jiaqi Li (ORCID: https://orcid.org/0000-0002-3218-5930)
- Ming Chen (ORCID: https://orcid.org/0000-0002-9677-1699)
- Jingjing Wang (ORCID: https://orcid.org/0000-0002-6006-2727)
- Guodong Zhang (ORCID: https://orcid.org/0000-0001-7780-5470)
- Xinru Wang (ORCID: https://orcid.org/0000-0001-5994-707X)
- Yuan Liao (ORCID: https://orcid.org/0000-0003-0534-6767)
- Hongwei Ouyang (ORCID: https://orcid.org/0000-0003-0627-2536)
- He Huang (ORCID: https://orcid.org/0000-0002-2723-1621)
- Lei Yang (ORCID: https://orcid.org/0000-0002-0333-9523)
- Peijing Zhang (ORCID: https://orcid.org/0000-0001-8301-1044)
- Mengmeng Jiang (ORCID: https://orcid.org/0000-0003-0040-7815)
- Tingbo Liang (ORCID: https://orcid.org/0000-0003-0143-3353)
Institutions
- Zhejiang Chinese Medical University (CN)
- Institute for Stem Cell Biology and Regenerative Medicine (IN)
- Zhejiang Institute of Mechanical and Electrical Engineering (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-08-31
- DOI
- https://doi.org/10.1002/ctm2.70461
- Citations
- 1
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Natural Science Foundation of Zhejiang Province