A Systematic Categorization of Performance Measures for Estimated Non‐Linear Associations Between an Outcome and Continuous Predictors

ABSTRACT In regression analysis, associations between continuous predictors and the outcome are often assumed to be linear. However, modeling the associations as non‐linear can improve model fit. Many flexible modeling techniques, like (fractional) polynomials and spline‐based approaches, are available. Such methods can be systematically compared in simulation studies, which require suitable performance measures to evaluate the accuracy of the estimated curves against the true data‐generating functions. Although various measures have been proposed in the literature, no systematic overview exists so far. To fill this gap, we introduce a categorization of performance measures for evaluating estimated non‐linear associations between an outcome and continuous predictors. This categorization includes many commonly used measures. The measures can not only be used in simulation studies, but also in application studies to compare different estimates to each other. We further illustrate and compare the behavior of different performance measures through some examples and a Shiny app. This article is categorized under: Statistical and Graphical Methods of Data Analysis > Modeling Methods and Algorithms

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Publication Details

Journal
Wiley Interdisciplinary Reviews Computational Statistics
Published
2025-08-31
DOI
https://doi.org/10.1002/wics.70042
Primary Topic
Health Systems, Economic Evaluations, Quality of Life
Type
article
Field-Weighted Citation Impact
0.00

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article

A Systematic Categorization of Performance Measures for Estimated Non‐Linear Associations Between an Outcome and Continuous Predictors

Willi Sauerbrei, Matthias Schmid, Georg Heinze, Theresa Ullmann et al.
1 links
Wiley Interdisciplinary Reviews Computational Statistics
Health Systems, Economic Evaluations, Quality of Life
article

A Systematic Categorization of Performance Measures for Estimated Non‐Linear Associations Between an Outcome and Continuous Predictors

Willi Sauerbrei, Matthias Schmid, Georg Heinze, Theresa Ullmann, Michał Abrahamowicz, Aris Perperoglou
article en

Abstract

ABSTRACT In regression analysis, associations between continuous predictors and the outcome are often assumed to be linear. However, modeling the associations as non‐linear can improve model fit. Many flexible modeling techniques, like (fractional) polynomials and spline‐based approaches, are available. Such methods can be systematically compared in simulation studies, which require suitable performance measures to evaluate the accuracy of the estimated curves against the true data‐generating functions. Although various measures have been proposed in the literature, no systematic overview exists so far. To fill this gap, we introduce a categorization of performance measures for evaluating estimated non‐linear associations between an outcome and continuous predictors. This categorization includes many commonly used measures. The measures can not only be used in simulation studies, but also in application studies to compare different estimates to each other. We further illustrate and compare the behavior of different performance measures through some examples and a Shiny app. This article is categorized under: Statistical and Graphical Methods of Data Analysis > Modeling Methods and Algorithms

Wiley Interdisciplinary Reviews Computational StatisticsVol. 17(3)
University of Freiburg (DE), Zimmer Biomet (Netherlands) (NL), University Hospital Bonn (DE), Age UK (GB), Institut für Medizinische Biometrie, Informatik und Epidemiologie (DE), McGill University (CA), Medical University of Vienna (AT)
Deutsche Forschungsgemeinschaft, Austrian Science Fund
Openalex Percentile: Top 69%
Health Systems, Economic Evaluations, Quality of Life
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