Intestinal Epithelial Integrity and Lactate Clearance are Maintained in Prolonged Normothermic Machine Perfusion prior to Intestinal Transplantation
Background: Intestinal transplantation is the only definitive treatment for patients with intestinal failure. However, success is hindered by epithelial barrier breakdown and subsequent bacterial translocation. The current static cold storage (CS) preservation method contributes to damage and is limited to 8 hours (H). Normothermic machine perfusion (NMP) has improved outcomes in other organ transplants. In prior work, NMP maintains epithelial architecture during 6H of storage with reduced damage, compared to CS, following in vivo reperfusion.
Authors
- Mohamed Mustafa (ORCID: https://orcid.org/0000-0003-1240-7679)
- Liara M. Gonzalez (ORCID: https://orcid.org/0000-0003-3972-2812)
- Elizabeth Goya‐Jorge (ORCID: https://orcid.org/0000-0003-0515-989X)
- Debra L. Sudan (ORCID: https://orcid.org/0000-0003-4315-4459)
- Ahmed O. Hassan (ORCID: https://orcid.org/0000-0002-9638-1260)
- Andrew S. Barbas (ORCID: https://orcid.org/0000-0003-3476-2313)
- Nader G. Abraham (ORCID: https://orcid.org/0000-0001-8983-1959)
- John Freund (ORCID: https://orcid.org/0009-0006-7530-4449)
- Caroline A. McKinney (ORCID: https://orcid.org/0000-0003-3167-2558)
- Lydia Poisson
- Juan Pesantez Valdivieso
- Carla Lopez-Cruz
Institutions
- North Carolina State University (US)
- Duke University (US)
Publication Details
- Journal
- Intestinal failure.
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.intf.2025.100109
- Primary Topic
- Clinical Nutrition and Gastroenterology
- Type
- article
- Field-Weighted Citation Impact
- 0.00