Micronutrient Supplementation in Long Term Teduglutide, a Single Centre Experience

Background: Crohn`s disease (CD) is a chronic and recurrent inflammatory disease.CD patients will develop short bowel syndrome due to high-output proximal stoma.These patients will always be dehydrated, experience electrolyte disturbance, weight loss, liver dysfunction and malnutrition.Methods: A retrospective cohort study of CD patients with high-out stoma receiving succus entericus reinfusion therapy combined with or without distal enteral nutrition feeding was undertaken.Data were obtained from thirty CD patients undergoing temporary proximal stoma and distal tube enterostomy.Liver function and nutrition status were compared after reinfusion therapy.Results: A total of 30 CD patients with high-output stoma were enrolled, with duration of stoma for 4 (3-4.25)months.Sixteen patients suffered emergency surgery and nine patients had prior bowel surgery.Twenty-seven patients had CD with structuring behavior.The length of small bowel proximal to the stoma was 160 (140-200) cm, and the distal length of small bowel was 100 (70-122.5)cm.The mean stoma output volume was 1025 (900-1515) ml before reinfusion therapy.Dehydrated, liver dysfunction, and electrolyte disturbance could be solved by succus entericus reinfusion therapy in all patients.However, body mass index (17.31.6 kg/m 2 vs 18.81.8kg/m 2 , P=0.032) and albumin (36.84.8g/Lvs 42.45.9g/L,P=0.010) were improved more effectively in patients combined with distal enteral nutrition feeding.Conclusions: Succus entericus reinfusion therapy combined with distal enteral nutrition feeding could provide an effective way to maintain hydration and nutritional status in CD with high temporary proximal stoma.