IBD-linked genetic variation in intestinal transplantation: a multicenter cohort analysis

Background: In solid organ transplantation, the intestine remains the most challenging. Previous studies have linked NOD2 genetic variation to intestinal transplantation (ITx) outcomes. Since then, a larger set of inflammatory bowel disease-associated genetic variants (IBDGVs) has been identified. This study aims to explore the prevalence and association of these IBDGVs with ITx outcomes.

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Publication Details

Journal
Intestinal failure.
Published
2025-01-01
DOI
https://doi.org/10.1016/j.intf.2025.100074
Primary Topic
Clinical Nutrition and Gastroenterology
Type
article
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article

IBD-linked genetic variation in intestinal transplantation: a multicenter cohort analysis

Gabriel Eduardo Gondolesi, Lisa Sharkey, Steffen Fieuws, Emilio Canovai et al.
Intestinal failure.
Clinical Nutrition and Gastroenterology
article

IBD-linked genetic variation in intestinal transplantation: a multicenter cohort analysis

Gabriel Eduardo Gondolesi, Lisa Sharkey, Steffen Fieuws, Emilio Canovai, Laurens Hannes, Maria V. Gentilini, Deborah Sarah Jans, Cleynen Isabelle, Andrew J. Butler, Christophe Chardot, Jacques Pirenne, Laurens J. Ceulemans, Florence Lacaille, María Lasa‐Lázaro, Jorge Calvo, Tim Vanuytsel, Sare Verstockt, Paloma Talayero, Lucas A. Wauters, Antoine Dubois, Irum Amin
article en

Abstract

Background: In solid organ transplantation, the intestine remains the most challenging. Previous studies have linked NOD2 genetic variation to intestinal transplantation (ITx) outcomes. Since then, a larger set of inflammatory bowel disease-associated genetic variants (IBDGVs) has been identified. This study aims to explore the prevalence and association of these IBDGVs with ITx outcomes.

Intestinal failure.Vol. 6
Hôpital Necker-Enfants Malades (FR), Consejo Nacional de Investigaciones Científicas y Técnicas (AR), Favaloro University (AR), University of Cambridge (GB), Churchill Hospital (GB), Research Institute Hospital 12 de Octubre (ES), Hospital Universitario 12 De Octubre (ES), Fundacion Favaloro Hospital Universitario (AR), Addenbrooke's Hospital (GB), KU Leuven (BE)
Openalex Percentile: Top 72%
Clinical Nutrition and Gastroenterology
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