ApoB-48 as a potential biomarker for treatment response with apraglutide in short bowel syndrome, intestinal failure and colon-in-continuity

regression with inverted probability of censoring weighting.The Score was externally validated in a separate cohort of 107 patients with CDIF from an independent tertiary IF unit.A severity classification, based on the CDIF-Wean Score, was evaluated with cumulative incidence curves for enteral autonomy and death.Results: In the CDIF-Wean Score, age, HPS duration, chronicity of CD, intestinal anatomy, and eligibility and type of reconstructive surgery was predictive of enteral autonomy.The Score performed well in discrimination and calibration in internal and external validation, respectively.The CDIF severity classification was significantly associated with shortand long-term prognosis, where mild patients had a 7.5, 5.8 and 5.2-fold higher probability of enteral autonomy than severe patients at 1, 5 and 10 years (p<0.0001).Conclusions: The CDIF-Wean Score is the first validated prediction model for IF outcomes, and demonstrates accuracy, robustness and generalisability in the prognostication of CDIF patients.