Reconsidering the immune pathway of intestinal transplant rejection: Novel insights from comparison with Crohn’s disease
Background: The mechanism of intestinal transplantation (ITx) rejection remains poorly understood but has been likened to that of Crohn’s disease (CD). We compared the mucosal immune responses in both states to test this hypothesis. Surprisingly, our findings suggest marked differences.
Authors
- Sarah Merl
- Charles Bevins (ORCID: https://orcid.org/0000-0003-2725-2622)
- Eric B. Nonnecke (ORCID: https://orcid.org/0000-0001-5345-2009)
- Mercedes Martínez (ORCID: https://orcid.org/0000-0001-6128-0155)
- Stephen M. Lagana
- Ying Kuen Cheung
- Megan Sykes
- Tomoaki Kato (ORCID: https://orcid.org/0000-0002-4593-4857)
- Abrar Shamim
- Julie Hong (ORCID: https://orcid.org/0000-0002-2035-0660)
- Hussein Atta (ORCID: https://orcid.org/0000-0003-1118-8347)
- Jianing Fu (ORCID: https://orcid.org/0000-0003-1500-5405)
- Joshua Weiner (ORCID: https://orcid.org/0000-0003-3780-1875)
Institutions
- Harvard University (US)
- Massachusetts General Hospital (US)
- Columbia University (US)
- University of California, Davis (US)
Publication Details
- Journal
- Intestinal failure.
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.intf.2025.100129
- Primary Topic
- Clinical Nutrition and Gastroenterology
- Type
- article
- Field-Weighted Citation Impact
- 0.00