Allograft Inflammation is Reduced with Normothermic Machine Perfusion in Intestinal Transplantation
Background: The only curative therapy for intestinal failure is transplantation. Intestinal transplantation (IT) following allograft static cold storage (CS) results in frequent rejection. Outcomes of other organ transplantation have improved with normothermic machine perfusion (NMP), partially through immune modulation. However, NMP in IT is nascent. Preliminarily, NMP stabilizes CD3+ lymphocytes while decreasing natural killer cells. We hypothesized that NMP reduces intestinal inflammatory signaling pathways and maintains the microbiome.
Authors
- Manuel Kleiner (ORCID: https://orcid.org/0000-0001-6904-0287)
- Elsa Ludwig
- Molly DuBois
- Katherine S. Garman (ORCID: https://orcid.org/0000-0001-7763-8465)
- Brittany Veerasammy (ORCID: https://orcid.org/0009-0006-7499-381X)
- Elizabeth Goya‐Jorge (ORCID: https://orcid.org/0000-0003-0515-989X)
- Cecilia R. Schaaf (ORCID: https://orcid.org/0000-0001-9900-8392)
- Nader Abraham (ORCID: https://orcid.org/0000-0001-9679-5642)
- Debra L. Sudan (ORCID: https://orcid.org/0000-0003-4315-4459)
- Ahmed O. Hassan (ORCID: https://orcid.org/0000-0002-9638-1260)
- D. L. ROSE (ORCID: https://orcid.org/0000-0003-1430-5692)
- Andrew S. Barbas (ORCID: https://orcid.org/0000-0003-3476-2313)
- John E. Freund
- Liara Gonzalez
- Carlos Aguirre (ORCID: https://orcid.org/0000-0001-5061-7509)
- Amy Stewart (ORCID: https://orcid.org/0000-0003-1602-3461)
- J. Alfredo Blakeley‐Ruiz (ORCID: https://orcid.org/0000-0001-7638-5849)
- Lydia Poisson
- Tobias Käser
Institutions
- North Carolina State University (US)
- Duke University (US)
Publication Details
- Journal
- Intestinal failure.
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.intf.2025.100103
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00