Protective and Regenerative Effects of IL-22 in Intestinal Transplant Rejection: A Potential Therapeutic Strategy?
Background: Acute cellular rejection (ACR) is a primary cause of graft failure and mortality in intestinal transplant (ITx) recipients, leading to mucosal barrier disruption and organ dysfunction. The IL-22/IL-22BP/IL-22R axis plays a crucial role in epithelial regeneration. This study evaluates the expression of this axis in ITx patients and the regenerative effects of recombinant IL-22 (rIL-22) in an allogeneic ITx rat model.
Authors
- Pablo Stringa (ORCID: https://orcid.org/0000-0002-6557-2160)
- M Gentilini
- Gabriel Eduardo Gondolesi (ORCID: https://orcid.org/0000-0002-3869-6213)
- Paula Constanza Arriola Benítez
- Ivana Ivanoff
- Natalia Lausada (ORCID: https://orcid.org/0000-0003-1686-6573)
- Anastasios D. Giannou (ORCID: https://orcid.org/0000-0002-4152-4201)
- Andrés Machicote
- Jeremías Moreira
- Samuel Huber (ORCID: https://orcid.org/0000-0001-9325-8227)
- Martín Rumbo
- Marco Santillán Pazmiño
Institutions
- Universität Hamburg (DE)
- Georgetown University (US)
- Favaloro University (AR)
- MedStar Georgetown University Hospital (US)
- University Medical Center Hamburg-Eppendorf (DE)
- Instituto de Física La Plata (AR)
- Universidad Nacional de La Plata (AR)
Publication Details
- Journal
- Intestinal failure.
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.intf.2025.100139
- Primary Topic
- Clinical Nutrition and Gastroenterology
- Type
- article
- Field-Weighted Citation Impact
- 0.00