The Effect of Anti‐3‐Hydroxy‐3‐Methylglutaryl‐ <scp>CoA</scp> Reductase ( <scp>HMGCR</scp> ) Human Autoantibodies on Muscle Regeneration in Mice
These findings establish the cytotoxicity of anti-HMGCR aAbs on regenerating muscle cells through a primarily complement-mediated mechanism, without directly impairing cellular regeneration per se. Given the still unmet medical needs of IMNM, C5 or upstream complement-targeted therapies early in the disease course, as well as aAb reduction, B/plasma cell depletion via CAR-T cells or bispecific antibodies deserves further clinical investigation.
Authors
- Sarah Julien
- Rachid Zoubaïri
- Thara Jaworski
- Olivier Boyer (ORCID: https://orcid.org/0000-0002-7591-307X)
- J. Martinet
- Laurent Drouot
- Honorine Tomasevic
Institutions
- Inserm (FR)
- Normandie Université (FR)
- Centre Hospitalier Universitaire de Rouen (FR)
- Université de Rouen Normandie (FR)
Publication Details
- Journal
- Muscle & Nerve
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/mus.70016
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Grifols