Yeasts and bacteria producing leukocyte interferon

Interferon alpha (IFN-α) is a cytokine with antiviral, antitumor, and immunomodulatory activity, and is widely used in the treatment of various diseases. Due to the high clinical significance of IFN-α, it is an urgent task to develop effective and economical methods for its production. One of the promising approaches is the use of recombinant technologies that make it possible to obtain IFN-α in large quantities in microbiological systems. This article is devoted to strategies for optimizing expression, the characteristics of various strains of microorganisms, and methods for isolating and purifying the target protein. The work summarizes modern achievements and prospects for the development of this field of biotechnology. Leukocyte interferon, due to its antiviral, immunomodulatory and antitumor properties, is a key component in the field of medical and pharmaceutical research. The article analyzes modern methods and approaches to the use of genetically modified microorganisms, including yeast of the genus Saccharomyces cerevisiae and bacteria such as Escherichia coli, for the production of leukocyte interferon.