High Affinity Dimeric Uracil-Based Receptor for the Recognition of Adenine Derivatives through Triplex-like Interactions
Adenine recognition through triplex-like interactions was explored using clamp-shaped artificial receptor <b>1</b>, bearing two uracil units and an extended naphthalene scaffold. The requisite binding mode was confirmed for 9-ethyladenine in CDCl<sub>3</sub> via NMR investigations. Phase-transfer experiments demonstrated that <b>1</b> selectively binds adenosine from an aqueous mixture of four ribonucleosides.
Authors
- Nicola Rivi
- Stefano Volpi (ORCID: https://orcid.org/0000-0002-1914-2338)
- Roberto Corradini (ORCID: https://orcid.org/0000-0002-8026-0923)
- Wolfgang Knoll (ORCID: https://orcid.org/0000-0003-1543-4090)
- Martina Neri (ORCID: https://orcid.org/0000-0002-2039-9026)
- Saša Korom (ORCID: https://orcid.org/0000-0003-4669-6739)
Institutions
- University of Parma (IT)
- Danube Private University (AT)
- Istituto Nazionale Biostrutture e Biosistemi (IT)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1021/acs.joc.5c01309
- Primary Topic
- DNA and Nucleic Acid Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Dipartimenti di Eccellenza
- Università degli Studi di Parma