Transforming growth factor beta (TGF-β) induces type 1 interferon signalling in systemic sclerosis keratinocytes through the chloride intracellular channel 4 (CLIC4)
This study shows the ability of CLIC4 to enhance TGF-β signalling is essential for aberrant type 1 interferon signalling in SSc skin.
Authors
- Emma Derrett‐Smith
- Christopher W. Wasson (ORCID: https://orcid.org/0000-0001-6558-4738)
- Ifeoluwa E. Bamigbola (ORCID: https://orcid.org/0000-0002-7415-2723)
- Enrico De Lorenzis (ORCID: https://orcid.org/0000-0002-1964-0601)
- Jessica Bryon
- Begoña Caballero-Ruiz (ORCID: https://orcid.org/0000-0001-5278-5573)
- Sophie Dibb
- Francesco Del Galdo (ORCID: https://orcid.org/0000-0002-8528-2283)
- Paul J. Meakin (ORCID: https://orcid.org/0000-0002-8553-3863)
- Stefano Di Donato (ORCID: https://orcid.org/0000-0003-2396-2061)
- Vishal Kakkar (ORCID: https://orcid.org/0000-0003-0513-8677)
- Yasser M. El‐Sherbiny (ORCID: https://orcid.org/0000-0003-4791-3475)
- Rebecca Wells (ORCID: https://orcid.org/0000-0002-6779-0663)
- Rebecca L. Ross (ORCID: https://orcid.org/0000-0001-7750-4280)
- Christopher P. Denton
- Eva M. Madourie-Clavane
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Leeds (GB)
- Agostino Gemelli University Polyclinic (IT)
- NIHR Leeds Musculoskeletal Biomedical Research Unit (GB)
- University College London (GB)
- Nottingham Trent University (GB)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1186/s13075-025-03632-6
- Citations
- 1
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Institute for Health and Care Research
- British Heart Foundation
- British Skin Foundation
- Directorate for Biological Sciences
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- Leeds Biomedical Research Centre