Left atrial appendage closure in patients with prior intracranial bleeding, safety, efficacy, and timing
Left atrial appendage occlusion is an effective and safe treatment alternative to reduce the risk of ischemic stroke in selected patients with atrial fibrillation and prior intracranial hemorrhage. In this study, we did not find differences regarding safety and efficacy in early closure compared with late closure. Further studies are needed to support early closure to reduce the complications associated with oral anticoagulation withdrawal.
Authors
- Gilles O’Hara (ORCID: https://orcid.org/0000-0002-1115-8108)
- David González Calle (ORCID: https://orcid.org/0000-0001-9051-0124)
- Pedro L. Sánchez (ORCID: https://orcid.org/0000-0002-1402-0526)
- Alejandro Francisco Barrero-Mier
- Pedro Cepas‐Guillén (ORCID: https://orcid.org/0000-0001-8814-7039)
- Luis López-Mesonero
- Ana Laffond (ORCID: https://orcid.org/0000-0002-1553-5652)
- Laura Sanchís (ORCID: https://orcid.org/0000-0003-2516-8953)
- Xavier Freixa (ORCID: https://orcid.org/0000-0002-3203-9060)
- Gema Tirado-Conde (ORCID: https://orcid.org/0000-0003-0400-1716)
- Ignacio J. Amat‐Santos (ORCID: https://orcid.org/0000-0002-2311-4129)
- Josep Rodés‐Cabau (ORCID: https://orcid.org/0000-0001-8237-7095)
- Hipólito Gutiérrez-García
- Pablo Salinas (ORCID: https://orcid.org/0000-0003-4040-4029)
- Ignacio Cruz‐González (ORCID: https://orcid.org/0000-0001-9742-6072)
- Luis Nombela-Franco y (ORCID: https://orcid.org/0000-0003-3438-8907)
- Alexandra González-Eras (ORCID: https://orcid.org/0000-0002-5305-7882)
- Jules Mesnier (ORCID: https://orcid.org/0000-0002-2131-6763)
- V. Peral
Institutions
- Hospital Clínico San Carlos (ES)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (ES)
- Hospital Clínico Universitario de Valladolid (ES)
- Université Laval (CA)
Publication Details
- Journal
- Neurología (English Edition)
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.nrleng.2025.07.009
- Citations
- 1
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.39