INFRAFRONTIER – the European Research Infrastructure for  In Vivo and  In Vitro Diseases Modelling

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d22427725e146">INFRAFRONTIER, is a non-profit organisation dedicated to advancing the understanding and treatment of human diseases through state-of-the-art <i>in vivo</i> and <i>in vitro </i>models. Comprised of a network of over 20 cutting-edge biomedical research institutes across Europe and beyond, INFRAFRONTIER enables the generation, phenotyping, archiving, and distribution of advanced mouse and rat models. It also supports the development and validation of <i>in vitro</i> model systems and the establishment of associated FAIR data resources. Moreover, INFRAFRONTIER offers the generation of germ-free animals for axenic and gnotobiotic experimentation in biomedical research, together with access to advanced Preclinical BioSafety Level 3 services for <i>in vivo</i> testing of infectious disease therapeutics. <p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" dir="auto" id="d22427725e160">Operating one of the world’s largest mouse repositories, INFRAFRONTIER empowers scientists in academia and industry to advance research into human health and disease. Committed to excellence, it applies rigorous and standardised protocols that prioritise animal welfare and supports the refinement, reduction, and replacement (3R) of animal models. Through close collaboration with other European research infrastructures, INFRAFRONTIER promotes the global exchange of FAIR research data and provides remote research services. These partnerships help to build a better connected European research community that can respond swiftly, effectively, and cooperatively to major health challenges. <p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" dir="auto" id="d22427725e162">INFRAFRONTIER leads the INFRAPLUS and PRIM-TECH3R projects, which will strengthen its capacity for human disease modelling, reduce animal use, and develop advanced <i>in vitro</i> models. Building on its expertise in model generation, characterisation, validation, collaborative research, and data integration, INFRAFRONTIER is well positioned for a significant contribution to drug repurposing in Europe and beyond.