The Impact of Age at First Sexual Intercourse on Female Reproductive Disorders: A Mendelian Randomized Study
Our research suggested that early AFS is closely associated with a higher risk of reproductive disorders, and timely interventions targeting BMI may partially alleviate the adverse effects of early sexual activity on reproductive health. The analysis based on genetic data emphasizes the importance of early sex education for adolescents, while weight management can to some extent avoid the occurrence of reproductive disorders during childbearing age, which also provide scientific basis for understanding the pathogenesis of FRDs and formulating appropriate reproductive health education strategies.
Authors
- Xin Xin (ORCID: https://orcid.org/0009-0000-7328-3193)
- Haicui Wu (ORCID: https://orcid.org/0000-0003-3313-3697)
- Jinfu Zhang (ORCID: https://orcid.org/0000-0002-5069-3496)
- Lu Guan (ORCID: https://orcid.org/0000-0002-7000-3894)
- Jiaxi Li (ORCID: https://orcid.org/0009-0000-6442-7642)
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine (CN)
- Zoucheng People's Hospital (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
- Shenzhen Pingle Orthopedic Hospital (CN)
Publication Details
- Journal
- International Journal of Women s Health
- Published
- 2025-09-01
- DOI
- https://doi.org/10.2147/ijwh.s534178
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province