Diaryl pyrimidine guanidine suppresses hepatocellular carcinoma cell stemness by targeting β-catenin signaling
C504244 represents a promising agent that effectively inhibits β-catenin signaling, thereby impairing CSCs properties and reversing Lenvatinib resistance in HCC cells. These findings suggest that C504244 may serve as a potential therapeutic agent for HCC.
Authors
- Dongxuan Ni
- Wei‐Lie Xiao (ORCID: https://orcid.org/0000-0001-6826-1993)
- Bin Liang (ORCID: https://orcid.org/0000-0002-8771-2646)
- Jinghui Cheng
- Rong Liu (ORCID: https://orcid.org/0009-0005-1327-112X)
- Ruihan Zhang (ORCID: https://orcid.org/0000-0002-7350-1370)
- Xuechun Chen
Institutions
- Yunnan University (CN)
- Peking University (CN)
- Southwest Forestry University (CN)
- Peking University Cancer Hospital (CN)
- Peking University First Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.3389/fonc.2025.1641979
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00