Integrated pan-cancer and melanoma-specific analysis of angiopoietin-2: prognostic value, immune microenvironment modulation, and ceRNA network regulation
ANGPT2 demonstrates potential as a biomarker for cancer diagnosis and prognosis, with evidence suggesting its involvement in immune microenvironment regulation and associated gene networks. Therapeutic approaches targeting ANGPT2, either as a stand-alone treatment or in combination with immunotherapies, could offer new and effective strategies for future cancer treatments.
Authors
- Xuejun Ni
- Qian Lin
- Hongteng Xie (ORCID: https://orcid.org/0009-0007-7855-9049)
- Beichen Cai (ORCID: https://orcid.org/0000-0002-6648-7873)
- Tao Huang (ORCID: https://orcid.org/0000-0003-4153-3607)
- Xiuying Shan (ORCID: https://orcid.org/0000-0002-3718-5075)
- Ruonan Ke (ORCID: https://orcid.org/0009-0001-5039-2685)
- Lu Chen (ORCID: https://orcid.org/0009-0009-4731-1264)
- Biao Wang (ORCID: https://orcid.org/0000-0001-7691-4368)
- H. Ye (ORCID: https://orcid.org/0000-0002-2764-6173)
- Xiaofen Wan
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Union Hospital (US)
- Union Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1007/s12672-025-03448-5
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fujian Normal University