Relationship between C-reactive protein/albumin ratio and lactate/albumin ratio and mortality in traumatic brain injury

We aimed to evaluate whether C-Reactive Protein/Albumin Ratio (CAR) and Lactate/Albumin ratio (LAR), which include acute phase reactants that are indicators of secondary brain injury processes such as inflammatory process, cytokine release, and hypoxia that develop after primary injury, are predictors of mortality in patients with traumatic brain injury (TBI). Patients who were admitted to the emergency department with a diagnosis of traumatic brain injury and stayed in the intensive care unit for more than 24 hours were included in the study. It was conducted by scanning the retrospective records of patients diagnosed with TBI between January 2022 and December 2023 in our hospital. As a result of our study, acute physiology and chronic health assessment II (APACHE II) and Injury Severity Score (ISS) were independent risk factors for mortality in TBI, while CAR and LAR were not independent variables in terms of mortality. Similar findings were valid for Glasgow Outcome Score (GOS). In addition, in patients who died; LAR, hypertension, high APACHE II score, low Glasgow Coma Scale (GCS), high ISS, mechanical ventilation requirements vasopressor requirements at first admission to intensive care, high lactate level, and low albumin levels were meaningful of the results. APACHE II and ISS were independent risk factors for mortality in TBI, while CAR and LAR were not independent variables in terms of mortality. Similar findings were valid for GOS. In addition, LAR levels were significantly higher in patients with ex. These results show us that LAR may be a parameter in mortality prediction.