Comparison of the Cytotoxicity, Internalization and Anti-Cancer Drug Delivery Efficacy of Nature Killer Cell Derived Nanovesicles and Extracellular Vesicles
Extrusion-derived NK-NVs offer a low-cost, rapid, and high-yield production method while selectively inducing cytotoxicity in cancer cells. Their pH-sensitive drug release enhances drug loading stability. These advantages establish NK-NVs as a promising and scalable platform for tumor immunotherapy and drug delivery with significant clinical potential.
Authors
- Rui Ye (ORCID: https://orcid.org/0000-0003-2473-0211)
- Dan Liang (ORCID: https://orcid.org/0000-0002-7617-0204)
- Xing Zhao (ORCID: https://orcid.org/0000-0001-7399-3777)
- Jinxi Zuo (ORCID: https://orcid.org/0000-0002-2188-1543)
- Xiaojin Lin (ORCID: https://orcid.org/0009-0003-5269-8703)
- Weili Guan (ORCID: https://orcid.org/0000-0002-5658-5509)
- Zailing Yang
- Ting Guo (ORCID: https://orcid.org/0000-0003-0199-5639)
- Yingchun Zhang (ORCID: https://orcid.org/0009-0009-3925-0107)
- Yuting Fan
- Jing Zhang (ORCID: https://orcid.org/0009-0004-0512-3816)
- Tao Shen (ORCID: https://orcid.org/0009-0009-3463-8567)
- Dan Fang
- Chulan Gong
- Liang Chen (ORCID: https://orcid.org/0000-0003-0563-2376)
Institutions
- Guiyang Medical University (CN)
- Anshun University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-09-01
- DOI
- https://doi.org/10.2147/ijn.s527756
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61