Zinc Therapy in Mild Cognitive Impairment: Cognitive Stabilization in Pharmacodynamically Responsive Patients in the ZINCAiD Trial
Zinc therapy stabilized cognition in a pharmacodynamically defined MCI subgroup. These exploratory findings suggest serum ceruloplasmin as a feasible biomarker of target engagement. Larger trials are needed for confirmation.
Authors
- Stefano L. Sensi (ORCID: https://orcid.org/0000-0002-0710-2574)
- Andrea Geviti (ORCID: https://orcid.org/0000-0003-0041-4142)
- Rosanna Squitti (ORCID: https://orcid.org/0000-0002-5624-1140)
- Alessandra Micera (ORCID: https://orcid.org/0000-0002-9375-6071)
- Silvia Fostinelli (ORCID: https://orcid.org/0000-0003-0120-880X)
- Alberto Granzotto (ORCID: https://orcid.org/0000-0001-9181-4373)
- Jasmine Rivolta (ORCID: https://orcid.org/0009-0002-1614-4861)
- Alberto Benussi (ORCID: https://orcid.org/0000-0002-8703-6940)
- Giuliano Binetti (ORCID: https://orcid.org/0000-0003-2759-5844)
- Mariacarla Ventriglia (ORCID: https://orcid.org/0000-0001-9797-8854)
- Mauro Rongioletti
- Roberta Ghidoni (ORCID: https://orcid.org/0000-0002-7691-1957)
- Matteo Santilli
- Alberto Albanese (ORCID: https://orcid.org/0000-0002-5864-0006)
- Barbara Borroni (ORCID: https://orcid.org/0000-0001-9340-9814)
Institutions
- University of Trieste (IT)
- Università degli Studi eCampus (IT)
- Agostino Gemelli University Polyclinic (IT)
- University of Chieti-Pescara (IT)
- Fondazione G.B. Bietti (IT)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- Ospedale SS. Annunziata (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- IRCCS Humanitas Research Hospital (IT)
- Azienda Sanitaria Universitaria Integrata di Trieste (IT)
- University of Brescia (IT)
- Catholic University of America (US)
Publication Details
- Journal
- Biomolecules
- Published
- 2025-09-01
- DOI
- https://doi.org/10.3390/biom15091268
- Citations
- 4
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 4.48
Funders
- Alzheimer's Association