Glycosylation of anti-dsDNA IgG correlates with organ involvement in treatment-naïve patients with systemic lupus erythematosus
Our study showed the effectiveness of combining glycoforms to classify and predict the degree of SLE organ involvement. Different glycoforms were correlated with the involvement degree to various extents, and the combination of anti-dsDNA IgG3/4Bis and IgG1Gal exhibited the best correlation with organ involvement.
Authors
- Yijun You (ORCID: https://orcid.org/0000-0002-3667-1258)
- Xiaobing Cheng (ORCID: https://orcid.org/0000-0002-1243-5170)
- Huihui Chi (ORCID: https://orcid.org/0000-0001-9587-1180)
- Dehao Zhu (ORCID: https://orcid.org/0009-0007-2229-1004)
- Jialin Teng (ORCID: https://orcid.org/0000-0003-1016-9064)
- Jinchao Jia (ORCID: https://orcid.org/0000-0003-1507-8540)
- Hui Shi (ORCID: https://orcid.org/0000-0002-3574-8807)
- Yue Sun (ORCID: https://orcid.org/0000-0003-2682-3542)
- Jianfen Meng (ORCID: https://orcid.org/0000-0001-8660-1170)
- P. Zhang
- Qiongyi Hu (ORCID: https://orcid.org/0000-0002-4825-5227)
- Chengde Yang (ORCID: https://orcid.org/0000-0002-3720-634X)
- H Zhang (ORCID: https://orcid.org/0009-0004-8860-4585)
- Junna Ye (ORCID: https://orcid.org/0000-0002-2823-4349)
- Cui Lu (ORCID: https://orcid.org/0000-0001-7008-296X)
- Shifang Ren (ORCID: https://orcid.org/0000-0001-8931-9293)
- Yutong Su (ORCID: https://orcid.org/0000-0002-0358-8933)
- Tingting Liu (ORCID: https://orcid.org/0000-0001-6043-3340)
- Yunping Cai (ORCID: https://orcid.org/0000-0002-2102-1498)
- Mengyan Wang (ORCID: https://orcid.org/0000-0002-8052-0828)
- Zhuochao Zhou
- Yuhong Liu
- Xiaotong Gu
- Jingyi Wu (ORCID: https://orcid.org/0000-0002-6970-911X)
Institutions
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Ruijin Hospital (CN)
- Songjiang District Central Hospital (CN)
Publication Details
- Journal
- Lupus Science & Medicine
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1136/lupus-2025-001665
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China
- Shanghai Rising-Star Program
- Fundamental Research Funds for the Central Universities