N(6)-methyladenosine modification of ADGRA3 by ZC3H13 suppresses papillary thyroid cancer cell malignancy by inactivating the PI3K/Akt/mTOR signaling pathway
This study uncovers a novel regulatory mechanism in which ZC3H13-mediated m<sup>6</sup>A modification of ADGRA3 suppresses PTC cell malignancy by inhibiting the PI3K/Akt/mTOR pathway. These findings highlight the potential of the ZC3H13/ADGRA3 axis as a therapeutic target for PTC, offering a unique and innovative approach to PTC therapy.
Authors
- Zhaodan Yan
- Cai Li (ORCID: https://orcid.org/0000-0002-3079-1451)
- Linghui Zhang
Institutions
- Wuhan University (CN)
- Wuhan No.1 Hospital (CN)
- Hubei Zhongshan Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1007/s12672-025-03482-3
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81